Why is Jet Relief™ So Effective?

Doctor Formulation

Jet Relief™ is a breakthrough formula that effectively combines the most powerful and extensively researched ingredients, giving you a dual-action solution for combating jet lag. Every single ingredient in Jet Relief™ was hand-picked by a team of medical doctors and scientific researchers, based on clinical data and designed to help reduce mental and physical stress during the journey, as well as, quickly balance sleep/wake cycles (circadian rhythms) upon arrival, and get results more effectively than any other jet lag remedy available.

Jet Relief™ contains 11 tested ingredients that meet the strength and purity standards of the USP/NF (United States Pharmacopeia–National Formulary). Each ingredient was carefully researched and included based on clinical data. No other non-prescription solution comes close in terms of quality and purity of ingredients.

Recommended use for adults is to take 2 capsules 30 minutes before take off and 2 capsules on arrival. Capsules should be taken a minimum of 4 hours apart. Consequently, take 1 capsule daily until the effects of jet lag have completely disappeared.

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Jet Relief™ - Comprehensive Blend of Ingredients:

    Magnesium supplementation is commonly used to combat stress and restlessness by promoting a sense of muscular and physical calm. One of the main symptoms of magnesium deficiency is chronic insomnia, so getting an adequate balance of magnesium is important to fighting fatigue. It is needed for a variety of basic bodily functions, including regulating your heart and positive benefits for blood pressure and nervous system. Furthermore, if the body does not have adequate levels of magnesium, the body cannot produce serotonin and melatonin, both essential in balancing mood and regulating sleep patterns. It is an essential mineral that works together with Calcium. A balanced ratio of these two minerals create important chemical activity to support a tired and stressed body.

    *References:
  1. Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences. 2012;17(12):1161-1169.
  2. Ayuk J., Gittoes N.J. (Mar 2014). "Contemporary view of the clinical relevance of magnesium homeostasis". Annals of Clinical Biochemistry 51 (2): 179–88
  3. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine (1997). Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D and fluoride. Washington DC: The National Academies Press. ISBN 0-309-06403-1
  4. Calcium is an essential element that acts as a signal for many cellular processes within the body and is an important component of a healthy diet. In order for the body to absorb calcium, it needs magnesium – and vice versa. Put simply, the role of calcium is to contract the muscles while, on the other hand, magnesium's job is to relax them. Deficiencies in Calcium can cause restlessness and wakefulness. Furthermore, during your flight, the body can become dehydrated. So, as well as drinking water, you need to replenish electrolytes such as calcium and magnesium. Magnesium and Calcium are essential for many enzyme reactions involved in energy metabolism.


    *References:
  5. Reid IR, Bristow SM, Bolland MJ (2015). "Calcium supplements: benefits and risks". J. Intern. Med. (Review).
  6. Dietary Supplement Fact Sheet: Calcium". Office of Dietary Supplements, NIH.
  7. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine (1997). Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D and fluoride. Washington DC: The National Academies Press. ISBN 0-309-06403-1.
  8. Vitamin B vitamins are essential for growth, development and many other bodily functions. These essential nutrients help convert our food into 'fuel', ensuring that we stay energized through the day, and of course, sleep well at night. If deficiencies occur, then a range of symptoms such as depression, fatigue and weakened memory may occur. Vitamin B6, B2 and B12 are included for optimal support to combat jet lag as well as elevate mood, increase attention and boost immunity.


    *References:
  9. Ebben, M.; A Lequerica; A Spielman (2002). "Effects of Pyridoxine on Dreaming: a Preliminary Study". Perceptual and Motor Skills 94 (1): 135–40. doi:10.2466/pms.2002.94.1.135. PMID 11883552. Retrieved 2012-05-23. The effect of pyridoxine (Vitamin B-6) on dreaming was investigated in a placebo, double-blind study to examine various claims that Vitamin B-6 increases dream vividness or the ability to recall dreams.
  10. Kashanian, M.; Mazinani, R.; Jalalmanesh, S. (2007). "Pyridoxine (vitamin B6) therapy for premenstrual syndrome". International Journal of Gynecology & Obstetrics 96 (1): 43–4.
  11. Vogiatzoglou A, Refsum H, Johnston C et al. (2008). "Vitamin B12 status and rate of brain volume loss in community-dwelling elderly". Neurology 71 (11): 826–32.
  12. L-ornithine is an amino acid which has the potential to relieve stress and improve sleep quality related to fatigue, ideal for overcoming jet lag. A variety of studies suggest that L-ornithine can promote a more efficient use of energy. Kidneys convert ornithine into arginine, which is a precursor for nitric oxide (NO2 production). NO2 boosts oxygen levels and supply to muscles and tissue promoting physical strength and endurance. Furthermore, it helps the body recover from physical exhaustion and promotes positive sleep patterns.


    *References:
  13. Mika Miyake, et. al., “Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers," Nutrition Journal 2014, 13:53
  14. Sugino, T; Shirai, T; Kajimoto, Y; Kajimoto, O (2008). "L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism". Nutrition research 28 (11): 738–43.
  15. Demura, S; Yamada, T; Yamaji, S; Komatsu, M; Morishita, K (2010). "The effect of L-ornithine hydrochloride ingestion on performance during incremental exhaustive ergometer bicycle exercise and ammonia metabolism during and after exercise". European journal of clinical nutrition 64 (10): 1166–71.
  16. L-theanine is an amino acid, that can both sharpen mental focus and calm anxiety at the same time. It is able to cross the blood-brain barrier as well as induce changes on alpha waves in the brain, promoting a relaxed and alert state at the same time. It has been studied for its potential to reduce mental and physical stress, as well as calming, relaxing and tranquilizing properties also.


    *References:
  17. K. Kobayashi et al., “Effects of L‑Theanine on the Release of Alpha-Brain Waves in Human Volunteers," Journal of the Agricultural Chemical Society of Japan 72, no. 2 (1998): 153–157.
  18. L-theanine. Review of Natural Products. Facts &Comparisons Online. April 2010.
  19. Kimura, Kenta; Ozeki, Makoto; Juneja, Lekh Raj; Ohira, Hideki (2007). "L-Theanine reduces psychological and physiological stress responses". Biological Psychology 74 (1): 39–45.
  20. GABA (Gamma-Amino Butyric acid) is a chemical made in the brain, which acts as a neurotransmitter in the central nervous system, and has been proven to have a natural calming effect, to relieve anxiety, and to improve mood. Early research shows that taking GABA reduces stress, tension, anxiety, confusion, and depression in people under pressure.


    *References:
  21. A. Abdou et al., “Relaxation and Immunity Enhancement Effects of Gamma- Aminobutyric Acid (GABA) Administration in Humans," BioFactors 26 (2006): 201–208.
  22. Ben-Ari Y, Gaiarsa JL, Tyzio R, Khazipov R (October 2007). "GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations". Physiol. Rev. 87 (4): 1215–1284.
  23. Chamomile (4:1) contains a vast array of compounds including flavonoids and coumarins which are considered smooth muscle relaxants. Chamomile has been used to to treat stress and insomnia, with studies demonstrating anxiolytic (anti-anxiety) and neuroendocrine effects.


    *References:
  24. Sarris, J; Panossian, A; Schweitzer, I; Stough, C; Scholey, A (December 2011). "Herbal medicine for depression, anxiety, and insomnia: a review of psychopharmacology and clinical evidence". European neuropsychopharmacology 21 (12): 841–860.
  25. Amsterdam JD, Li Y, Soeller I, Rockwell K, Mao JJ, Shults J (2009-08-29). "A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder.". Journal of Clinical Pharmacology 29 (4): 378–82.
  26. Singh, O; Khanam, Z; Misra, N; Srivastava, MK (January 2011). "Chamomile (Matricaria chamomilla L.): An overview.". Pharmacognosy reviews 5 (9): 82–95.
  27. Srivastava, JK; Shankar, E; Gupta, S (November 2010). "Chamomile: A herbal medicine of the past with bright future". Molecular medicine reports 3 (6): 895–901.
  28. Gardiner, P (2007). "Complementary, Holistic, and Integrative Medicine: Chamomile". Pediatric Review 28 (4): 16–18.
  29. Ashwagandha (Withania somnifera) is a plant used in Ayurvedic medicine as an “adaptogen" herb for the treatment of stress, fatigue, lack of energy, and difficulty sleeping. Scientific studies support ashwagandha's ability not only to relieve stress, but also to protect brain cells against the deleterious effects of our modern lifestyles. Reported benefits include an increase in energy, reduction in fatigue, enhanced sleep, and an elevated sense of well-being.

    *References:
  30. Mirjalili, M. H.; Moyano, E.; Bonfill, M.; Cusido, R. M.; Palazón, J. (2009). "Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine". Molecules 14 (7): 2373–2393.
  31. Pandit, S.; Chang, K.-W.; Jeon, J.-G. (February 2013). "Effects of Withania somnifera on the growth and virulence properties of Streptococcus mutans and Streptococcus sobrinus at sub-MIC levels". Anaerobe 19: 1–8.
  32. Bhattacharya SK, Bhattacharya A, Sairam K, Ghosal S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Phytomedicine. 2000 Dec;7(6):463-9.
  33. DMAE Bitartrate is present in small amounts in our brains and can enhance mental activities, elevate mood, improve memory and learning and increase physical energy. DMAE has been proven to increase the production of brain chemicals essential for sleep regulation, memory, and concentration, as well as, have positive influence on mood. It is a precursor for choline, which is present inside cells, that is converted to phosphatidylcholine and is used in the building and repair of cell membranes, particularly within the brain, acting as a “neurotransmitter" that helps nerve cells communicate. Some suggest that the effects of DMAE are similar to caffeine but more gradual and continuous. It is used for treating a variety of conditions including attention deficit-hyperactivity disorder (ADHD), Alzheimer's disease, autism as well as boosting thinking skills and intelligence; and increasing physical energy, oxygen efficiency, athletic performance, and muscle reflexes.


    *References:
  34. Lukoshko SO, Koval'chuk TO, Rybal'chenko VK. The effect of dimethylethanolamine on the summation capacity of the central nervous system and on the work capacity of animals in a chronic experiment. Fiziol Zh 1997;43(1-2):19-22.
  35. Pfeiffer, C. C.; Jenney, E. H.; Gallagher, W; Smith, R. P.; Bevan Jr, W; Killam, K. F.; Killam, E. K.; Blackmore, W (1957). "Stimulant effect of 2-dimethylaminoethanol; possible precursor of brain acetylcholine". Science (New York, N.Y.) 126 (3274): 610–1.